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DAVID GREENE, HOST:

As Mara just mentioned, the debate last night opened with a question about a claim made by Gingrich's ex-wife. Well, Marianne Gingrich gave her exclusive interview to ABC's "Nightline," putting the candidate's personal life in the spotlight once again. NPR's Tamara Keith has more.

TAMARA KEITH, BYLINE: The interview was incredibly hyped, in part because Marianne Gingrich has been silent so far on her ex-husband's presidential candidacy. This was her first television interview since their 1999 divorce.

Renee Montagne has the Last Word in business.

On the campaign trail, GOP presidential candidate Rick Santorum often discusses his opposition to abortion rights and gay marriage. That message served him well in Iowa with its large contingent of evangelical voters. Christian conservatives are also dominant in South Carolina, which votes Saturday. Santorum hopes to repeat his Iowa performance, but he's been struggling to keep pace in polls.

GOP presidential campaigns and superPACs have been spending millions of dollars on TV and radio advertising ahead of Saturday's South Carolina primary. While the negative superPAC ads air, the candidates are delivering a more positive message.

David Greene has business news.

Saturday is South Carolina's Republican presidential primary. It's also the second anniversary of the Supreme Court's famous Citizens United decision.

That's the case that allows corporations to explicitly support or attack specific candidates. The day will be marked with attack ads — and protests.

The Republican presidential race has covered just three states so far. And superPACs linked to candidates Mitt Romney, Newt Gingrich, Rick Santorum and Ron Paul have spent a total of $20 million. They're feeding voters a heavy diet of negativity.

In 1999, Rene Foreman was diagnosed with esophageal cancer. She underwent surgery that saved her life; it also took her voice box. To speak, Rene now uses an electrolarynx — a small device that she holds against her throat to produce her voice, electronically.

Discussing how having a synthesized voice has changed her life, Rene, 70, told her daughter Michelle that the electrolarynx helps her to enjoy each day, even if it also makes her stand out in some ways.

Of those times, Michelle asks, "How do you feel when people turn around and look at you?"

Megaupload, one of the world's most popular file-sharing sites, was shut down Thursday as its founder and several executives were charged with violating piracy laws by the U.S. Department of Justice. As a technology used to transfer files too large to be sent by email, Megaupload has perfectly legitimate uses, but the Motion Picture Association of America claims that most of the content transferred over the site violates U.S. copyright laws.

Wikipedia was shut down on Wednesday to protest anti-piracy bills in Congress. But Twitter was there to fill the encyclopedic void. "Facts Without Wikipedia" became a trending topic. One tweet informed readers that Star Wars was based on the work of William Shakespeare.