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Tuberculosis specialists in India have diagnosed infections in a dozen patients in Mumbai that are unfazed by the three first-choice TB drugs and all nine second-line drugs.

The doctors are calling them "totally drug-resistant TB," and the infections are essentially incurable with all available medicines.

Michael J. Williams said he is stepping down as chief executive of the quasi-governmental mortgage giant Fannie Mae. The company made the announcement late last night, saying Williams will wait to step down until the board of directors names a successor.

"I decided the time is right to turn over the reins to a new leader," Williams said in a statement.

Twinkies maker Hostess Brands Inc., is again seeking protection from its creditors, filing for Chapter 11 bankruptcy as the company tries to cope with high debt and rising costs of labor and raw materials.

Hostess, which also makes Ho Hos, Sno Balls, and Wonder Bread, is a privately held company based in Irving, Tex. It owes millions to suppliers and labor unions. The company has reportedly found some financing to keep it running during bankruptcy proceedings.

For our Newscast desk, Larry Abramson reports:

Pakistani officials say the United States launched a drone strike early Wednesday morning for the first time since November. The AP says the drone strike killed four in North Waziristan, which is close to the Afghan border and has been a hot spot for U.S. strikes.

An Iranian nuclear scientists was killed by a car bomb in Tehran this morning, Iran's official news agency said. According to Press TV, Iran's English-language outlet, a magnetic bomb was placed beneath Mostafa Ahmadi Roshan's car by a man in a motorcycle.

Press TV says Roshan and his driver were killed and a bystander was injured. Roshan was a "chemical engineering graduate and served as marketing deputy of Iran's Natanz nuclear facility."

Mitt Romney's convincing win in New Hampshire — and what that might mean for upcoming contests in the Republican presidential race — is the subject of a special podcast prepared fresh this morning from NPR News.

The podcast includes highlights from what the candidates had to say about the outcome in New Hampshire, plus NPR reporting on how Romney put together his victory. It also examines how the focus of the campaign will change as the GOP hopefuls descend on South Carolina ahead of that state's Jan. 21 primary.

Now it's South Carolina's turn.

If the Palmetto State, the "First in the South" primary, plays its traditional role in the Republican presidential nomination process, it will be where the White House hopes of virtually every candidate except the eventual nominee will go to die in about 10 days.

It's not for nothing that it's called the "South Carolina Firewall." And at this moment, it's looking like it's Romney's firewall.

There's a new award for brutal book reviews in Britain: the Hatchet Job of the Year Award. A Julian Barnes book is dismissed as "just so... average." A biography of Martin Amis is called "spectacularly bad writing about spectacularly good writing."

Ben Motz of Indiana University looked at NFL games over a 25-year span, and found the home team won 57 percent of the time. Professor Motz did find the home team's winning percentage dropped with the advent of instant replay.